Brock Purdy threw for 303 yards and three touchdowns as San Francisco is now one win away from earning the NFC's top seed.

Mailbag covers Jordan Elliott's knee, how SF can stop Jonathan Taylor, and what fans want for Christmas this NFL season.

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

Expert recap and game analysis of the San Francisco 49ers vs. Tennessee Titans NFL game from December 14, 2025 on ESPN.

AMC has revealed the official trailer for a docuseries about the San Francisco 49ers. On Thursday, the network shared the trailer for Rise of the 49ers, and it starts with Tom Brady, a lifelong 49ers ...

There's value hiding in plain sight as the Indianapolis Colts' conservative offense takes on the San Francisco 49ers.

SANTA CLARA, Calif. — SANTA CLARA, Calif. (AP) — Brock Purdy threw three touchdown passes and the San Francisco 49ers started the stretch run of their season with a 37-24 victory over the Tennessee ...

Jeffery Simmons made a remarkable impact for the Tennessee Titans in their 37-24 loss to San Francisco on Sunday. In the ...

Cleveland Browns All-Pro edge rusher Myles Garrett is on the doorstep of NFL history. His 21.5 sacks lead the league by a ...