Brain cells (magenta) in the reward center of a rat’s brain release dopamine in response to opioids. According to a new study by WashU Medicine researchers, male and female rats with a chronic pain ...

More good news in the battle against opioid addiction. Scientists have reopened research into a class of opioids that were ...

Is there a safe opioid? Scientists discovered DFNZ, a high-potency nitazene that relieves pain without the risk of overdose ...

While opioids are incredibly powerful pain management tools, they can also be highly addictive. Since 2013, the rate of deaths from an overdose due to synthetic opioids, like fentanyl, has steadily ...

Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as ...

Using a long-abandoned class of opioids as their starting point, scientists have discovered an opioid painkiller that doesn't ...

Scientists have developed a new gene therapy that quiets pain at its source in the brain—without the addictive risks of opioids. Using AI to map how pain is processed, they created a targeted “off ...

Researchers found that opioids offer only limited pain relief for some pain conditions, such as dental surgery and traumatic limb pain. But they were not better than a placebo for things like kidney ...

There are effective alternatives to these highly addictive drugs. Opioids provide limited, short-term relief for some acute pain, not better than an alternative for others. Opioids increase side ...