Longevity science has spent decades chasing single molecules that might slow aging, but most candidates have delivered modest ...

A research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating ...

A small tweak to mitochondrial energy production led to big gains in health and longevity. Mice engineered to boost a protein that helps mitochondria work more efficiently lived longer and showed ...

Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system acts like ...

He found that heat rapidly impaired electron transport chain complex 1 (ETC1), a mitochondrial protein complex that generates energy. ETC1 impairment set off signaling mechanisms that led to DNA ...

(A) MRPS29 interacts with ADAR2 and represses A-to-I RNA editing by disrupting the association of ADAR2 with dsRNA, which induces the accumulation of PDZD7WT in cells to promote cancer. (B) MRPL9 ...

Jeffrey Rathmell, PhD, left, and Darren Heintzman have defined the molecular events of the T cell response to fever temperatures. Fever temperatures rev up immune cell metabolism, proliferation and ...

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also—in a particular subset of T cells—cause mitochondrial stress, DNA damage and cell death, Vanderbilt ...