Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy. The BSA-based method of dose calculation was adopted without adequate investigation of its ...

Body surface area-dosing does not account for the complex processes of cytotoxic drug elimination. This leads to an unpredictable variation in effect. Overdosing is easily recognised but it is ...

How many of us give a “full” dose of chemotherapy to an obese patient—even in the curative setting? Dose calculation in the obese is a confusing but important puzzle for the oncologist and is becoming ...

OBJECTIVE: To compare 8 mg/kg and 6 mg/kg loading doses of aminophylline. STUDY DESIGN: Sixty-one preterm infants weighing <1500 g were enrolled once a decision to administer intravenous aminophylline ...