The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cascade is a signal transduction pathway that was originally identified in the vertebrate system 1, 2 and has been ...

Are inhibitors of the JAK/STAT Signaling Pathway a potential treatment for Parkinson Disease? How does -syn lead to activation of the JAK/STAT pathway, and how does this contribute to ...

The JAK/STAT (Janus Kinase-Signal Transducer and Activator of Transcription) signalling pathway controls the activity of various cytokines and growth factors. The ...

Positron emission tomography (PET) and estrogen receptor (ER) ligand in patients with invasive breast cancer. Germline single nucleotide polymorphisms (SNPs) in XRCC3, XRCC1, and XPD, and survival ...

Acute myeloid leukemia (AML) is a deadly hematologic malignancy with poor prognosis, particularly in the elderly. Even among individuals with favorable-risk disease, approximately half will relapse ...

Jonathan Silverberg, MD, PhD, MPH, associate professor of dermatology, director of clinical research and patch testing, George Washington University School of Medicine and Health Sciences, discusses ...

The development of a complex animal from a single egg cell requires both cell division and cell specialization to produce the different organs and structures required for adult life. In order to be ...

Research led by a University of Maryland team has identified the first inter-species signaling pathway between an arthropod parasite and host, where molecules in the blood of a host animal triggers ...

First patient dosed in Phase I/II HEMA-MED clinical trial (NCT06887803) evaluating the tolerability and efficacy profile of roginolisib (PI3Kδ inhibitor) plus ruxolitinib in myelofibrosis (MF) ...

Please provide your email address to receive an email when new articles are posted on . NEW YORK — Systemically administered Janus kinase inhibitors hold potential for the treatment of alopecia areata ...