How would you summarize your study for a lay audience? Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause inflammation during an asthma ...

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...

Mast cells are pivotal effectors in immune responses, acting as both sentinels and mediators in allergic and inflammatory processes. Their ability to rapidly degranulate and release a myriad of ...

Q: My doctor thinks my mast cells are activating inappropriately and may be causing many of the symptoms I periodically have. Please tell me more about this condition. A: Mast cells are an important ...

Third in a series of articles on COVID-19 and its effects on the gut, this article will explore “Long COVID” (also called ...

Allakos is a clinical stage biotechnology company developing therapeutics which target immunomodulatory receptors present on immune effector cells involved in allergy, inflammatory and proliferative ...

According to the National Center for Health and Statistics, under the Centers for Disease Control and Prevention (CDC), ...

For many patients with diverse and seemingly unrelated symptoms, obtaining an accurate diagnosis can take years of specialist visits and inconclusive tests. Mast cell activation syndrome, a disorder ...

A new way of treating common inflammatory skin conditions such as eczema is on the horizon, according to a new study. American researchers discovered that a compound called SYM2081 inhibited ...

A new approach to treat rosacea and other inflammatory skin conditions could be on the horizon, according to a University of Pittsburgh study published today in Science Translational Medicine. The ...

In a mouse model of contact dermatitis, preventive application of a cream containing SYM2081 (right image) reduced skin swelling compared to placebo (left image). A new approach to treat rosacea and ...