A research team led by Purdue University's W. Andy Tao has discovered a new type of protein modification related to cellular mutation that impairs a crucial enzyme's ability to help drive energy ...

Thus, ArcS is an unprecedented tRNA modification enzyme that can act on a nucleoside as the substrate. With the development of mRNA vaccines for COVID-19, modified nucleosides like pseudouridine and 1 ...

Linker that joins up Rubisco cuts synthesis of toxic byproduct that plants pay a heavy energy price to deal with ...

We have synthesized a hybrid subtilisin the solubility of which can be regulated by photoirradiation through coupling with a photoresponsive copolymer that carries spiropyran groups in its side chains ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including ...

Sanofi has developed a simpler way to create site-specific antibody-to-mannose-6-phosphate (M6P) conjugates that eliminates the need for enzyme remodeling. This more straightforward method makes M6P ...

Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to produce viral proteins and thus spread more quickly. This is the main ...

Proteins are the workers in a cell and, as the "basic element of life", are responsible for the most widely varying metabolic processes. In plants, for example, they take on an important function in ...

This method uses polymer modifications to tune enzyme activity for increased solubility in non-native solvents. Tuning the miscibility of enzymes in non-native solvent environments has important ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...