Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Cancer cells can disarm the immune system not just by hiding from it, but by actively reprogramming nearby immune cells into ...

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Immune checkpoint blockade (ICB) has reshaped modern immunotherapy by unleashing antitumor immune responses through targeting inhibitory immune checkpoints ...

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of ...

Building on the concept that blocking differentiation into specialized cell types maintains stem cells, USC and NIH scientists identify GSK3α as a checkpoint across diverse stem cell types. A study ...

Researchers in the lab of Jean Cook, Ph.D., chair and professor in the Department of Biochemistry and Biophysics, have identified the cellular processes that occur when you take a cancer drug meant to ...

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages ...

Red indicates mouse embryonic stem cells and green indicates mouse epiblast stem cells. The two cell types were co-cultured under GSK3α inhibition and maintained their distinct identities. A study ...